Image: Summary of fndings. AMPK phosphorylation was lowered in the colon and hypothalamus after High Sugar High Fat (HSHF) intake

Obesogenic diets (ODs) can affect AMPK activation in several sites as the colon, liver, and hypothalamus. OD intake can impair the hypothalamic AMPK regulation of energy homeostasis.

Our results highlight the relevance in multi-organ investigations and animal phenotype evaluation when studying the energy metabolism regulations.”

Read the article: AMPK in the gut-liver-brain axis and its influence on OP rats in an HSHF intake and WTD rat model, Pflügers Archiv, European Journal of Physiology, DOI: 10.1007/s00424-021-02583-6

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